Major Clinical Trial Low-Dose Recombinant Tissue-Type Plasminogen Activator Enhances Clot Resolution in Brain Hemorrhage The Intraventricular Hemorrhage Thrombolysis Trial
نویسندگان
چکیده
Neal Naff, MD; Michael A. Williams, MD; Penelope M. Keyl, PhD; Stanley Tuhrim, MD; M. Ross Bullock, MD; Stephan A. Mayer, MD; William Coplin, MD; Raj Narayan, MD; Stephen Haines, MD; Salvador Cruz-Flores, MD; Mario Zuccarello, MD; David Brock, MD; Issam Awad, MD; Wendy C. Ziai, MD, MPH; Anthony Marmarou, PhD; Denise Rhoney, PharmD; Nichol McBee, MPH, CCRP; Karen Lane, CCRP; Daniel F. Hanley, Jr, MD
منابع مشابه
Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.
BACKGROUND AND PURPOSE Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricular clot lysis. METHODS Forty-eight patients were enrolled at 14 centers an...
متن کاملSystemic hematologic status following intraventricular recombinant tissue-type plasminogen activator for intraventricular hemorrhage: the CLEAR IVH Study Group.
BACKGROUND AND PURPOSE This is the first prospective evaluation of changes in systemic hematologic status following administration of intraventricular recombinant tissue-type plasminogen activator in patients with intraventricular hemorrhage (IVH). METHODS Laboratory data from subjects enrolled onto the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) Trials were analyzed. We ...
متن کاملDual frequency ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro human clot model
Introduction: Stroke causes death and disability in patients throughout the world. At present, the only FDA- approved drug for ischemic stroke is recombinant tissue plasminogen activator (rt- PA). Unfortunately, rtPA can cause intracerebral hemorrhage and must use within limited time window (within 3-4.5 hour after onset of stroke). Ultrasound with rtPA loaded liposomes (rtPA_L...
متن کاملFactors affecting clot lysis rates in patients with spontaneous intraventricular hemorrhage.
BACKGROUND AND PURPOSE In the treatment of severe intraventricular hemorrhage (IVH), thrombolytic use and clot size are known to influence clot lysis rates. We evaluated the effect of other variables on IVH clot lysis rates among patients treated with recombinant tissue-type plasminogen activator or placebo. METHODS One hundred patients with IVH and intracerebral hemorrhage volume <30 mL requ...
متن کاملBleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial.
BACKGROUND Retrospective series report varied rates of bleeding and infection with external ventricular drainage (EVD). There have been no prospective studies of these risks with systematic surveillance, threshold definitions, or independent adjudication. OBJECTIVE To analyze the rate of complications in the ongoing Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage ...
متن کامل